Tumor Budding en Cáncer Rectal. Relación entre la Densidad de los Brotes Tumorales y Otros Factores Pronósticos

Javier  Chinelli; Viviana  Escobar; Valentina  Porro; Emilia  Moreira; Gustavo  Rodríguez; Elisa  Laca

Javier Chinelli Cirujano, Clínica Quirúrgica 2, Hospital Maciel.
Viviana Escobar Patóloga. Depto de Anatomía Patológica, Hospital Maciel.
Valentina Porro Patóloga. Depto de Anatomía Patológica, Hospital Maciel.
Emilia Moreira Residente de Cirugía General, Clínica Quirúrgica 2, Hospital Maciel.
Gustavo Rodríguez Cirujano. Profesor Titular Clínica Quirúrgica 2, Hospital Maciel.
Elisa Laca Patóloga. Jefa del Depto de Anatomía Patológica del Hospital Maciel.

Keywords: Tumor Budding, Rectal Cancer, Prognostic Factor

Abstract

Introduction: Tumor budding (BT) is defined as isolated or small groups of neoplastic cells located at the invasive front of the tumor. High-grade BT is a poor prognostic factor in colorectal cancer.
Objective: To determine if the degree of BT is associated with other prognostic factors in rectal cancer.
Materials and methods: Rectal oncological resections during the 2013-2017 period were included. Cases were stratified according to the density in the formation of BT in 3 groups: low, intermediate and high. The calculation of the odds ratio (OR) was used as a statistical value.
Results: The resection specimens of 27 patients (15 women and 12 men) with a mean age of 68.4 years (40-86) were analyzed. OR for node metastases, vascular invasion and relapse was calculated according to tumor budding grade.
Discussion: High-grade tumor budding seems to associate with the presence of poor prognostic factors. However, it was not possible to demonstrate it because of the small sample size.
Conclusions: Tumor budding is a reproducible marker and could help to identify rectal cancer patients with a worse prognosis.